Red Ice News

The Future is the Past

Gene editing technique could transform future
New to Red Ice? Start Here!

Gene editing technique could transform future

Source: bbc.com

CRISPR - get to know this acronym. It's good to know the name of something that could change your future.

Pronounced "crisper", it is a biological system for altering DNA. Known as gene editing, this technology has the potential to change the lives of everyone and everything on the planet.

A bold statement but that is the considered view of many of the world's leading geneticists and biochemists I've spoken to in recent months when working on my latest Panorama - Medicine's Big Breakthrough: Editing Your Genes.

CRISPR was co-discovered in 2012 by molecular biologist Professor Jennifer Doudna whose team at Berkeley, University of California was studying how bacteria defend themselves against viral infection.

Prof Doudna and her collaborator Emmanuelle Charpentier are now among the world's most influential scientists. The natural system they discovered can be used by biologists to make precise changes to any DNA.

She told me: "Since we published our work four years ago laboratories around the world have adopted this technology for applications in animals, plants, humans, fungi, other bacteria: essentially any kind of organism they are studying."

Cancer target

There are several recently-formed biotech firms which are hoping to take CRISPR technology into the clinic.

They are working on the theory that CRISPR might be used to boost the function of the body's T cells so that the immune system is better at recognising and killing cancer. Disorders of the blood and immune system are other potential targets.

One cloud hanging over all this effort is a big patent fight over CRISPR. On one side are Prof Doudna's team, on the other a group based in Boston, Massachusetts.

The patent row is unlikely to prevent academic researchers from using CRISPR, but it could have a profound impact on who reaps the financial returns of this emerging technology.

Two earlier forms of gene editing have already made it into the clinic.

Last year a technique known as TALENs was used to help reverse cancer in a patient at London's Great Ormond Street Hospital.

Layla Richards had an aggressive form of leukaemia, and all previous treatments had failed. She remains the first and only person to date whose life has been saved by gene editing.

The world's first gene-editing trials took place in California, involving a different technique, ZFNs. Around 80 patients with HIV had immune cells in their blood removed.

Scientists then deleted a gene called CCR5 which HIV uses to gain entry to cells. The treatment is based on a rare, gene mutation which gives some people a natural immunity to the disease.

One of the volunteers was Matt Chappell, 52, who has lived with HIV most of his adult life and witnessed the devastating impact that HIV/Aids has had on the gay community in San Francisco.

Matt has been off all antiretroviral medication for two years since having his immune cells gene edited.

These were small trials so caution is needed before reading too much into the results, but they are nonetheless extremely promising.

The HIV treatment was created by Sangamo Biosciences of Richmond, California, which has the exclusive licence for ZFN technology.

The company is about to begin patient trials in the serious blood-clotting disorder haemophilia and is also working on a treatment for beta thalassemia.

The most controversial aspect of gene editing concerns the potential to introduce changes to the germline - DNA alterations that would pass down the generations.

In theory it might be possible to correct the DNA of embryos carrying the gene for Huntington's disease or cystic fibrosis.

But it might also be used to add in genetic enhancements, leading to designer babies.

Human embryos

No scientist is suggesting - yet - that gene-edited human embryos should be born. But several teams in China have done some basic research and the UK is the first country to formally approve gene editing in human embryos, for research only.

This will be done at the Francis Crick Institute in London. When it opens in a few months it will be the biggest biomedical laboratory in Europe and will be a centre for gene editing.

A team led by Kathy Niakan - recently named by Time magazine as one of the world's 100 most influential people - will use CRISPR to edit out key genes from the embryo, to try to identify the genetic faults which lead many women to repeatedly miscarry. The embryos will be allowed to develop for just a few days.

She told me: "What I'm hoping is that it provides us with a really crucial insight into early human development.

"I think it could help in identifying ways in which we could improve IVF to identify those embryos that are likely to continue to develop and thrive and, and give rise to healthy babies."

Ethical concerns

But this research rings ethical alarms bells for Marcy Darnovsky of San Francisco's Center for Genetics and Society.

She believes human embryo editing research may not be adequately controlled, leaving it open to a lab somewhere to create the first gene-edited babies.

"You could find wealthy parents buying the latest offspring upgrades for their children. We could see the emergence of genetic haves and have nots, leading to even greater inequality than we already live with."

Some of the key scientists in this field have concerns about the potential misuse of a technology that could be used for eugenics, to create genetic discrimination.

Prof Doudna told me of a nightmare she had where she was led into a dark room where a man was seated with his back to her.

She said: "When he turned I realised with horror that it was Hitler and I was being expected to discuss this technology with him and he eagerly wanting to use it."

She says that that while it is very hard to regulate the use of CRISPR technology, it is important to find a consensus about how people should proceed.

"I never want to over-promise but I feel diseases will be cured and we want to enable clinicians and scientists to bring that to a reality."

Comments

We're Hiring

We are looking for a professional video editor, animator and graphics expert that can join us full time to work on our video productions.

Apply

Help Out

Sign up for a membership to support Red Ice. If you want to help advance our efforts further, please:

Donate

Tips

Send us a news tip or a
Guest suggestion

Send Tip

Related News

The Future Will Be Our Past and the Past Will Be Our Future
The Future Will Be Our Past and the Past Will Be Our Future
Gene Editing Reveals New Insights About Early Human Development
Gene Editing Reveals New Insights About Early Human Development

Archives Pick

Red Ice T-Shirts

Red Ice Radio

3Fourteen

Film & Expose Your Marxist Professor
Vincent Foxx - Film & Expose Your Marxist Professor
Maine Town Manager Fired For Political Views
Tom Kawczynski - Maine Town Manager Fired For Political Views

TV

Nancy Loves Antonio Just Because He's Brown
Nancy Loves Antonio Just Because He's Brown
Film & Expose Your Marxist Professor
Vincent Foxx - Film & Expose Your Marxist Professor

RSSYoutubeGoogle+iTunesSoundCloudStitcherTuneIn

Design by Henrik Palmgren © Red Ice Privacy Policy